(CNN) — More than 10 children on average have lost one or both of their legs every day in Gaza since October 7, with many amputations performed without anesthesia, a charity said Sunday, underscoring the dire humanitarian situation in the Palestinian enclave following more than three months of Israeli bombardment.

In a statement citing United Nations statistics, Save the Children’s director for the occupied Palestinian territory, Jason Lee, said the “suffering of children in this conflict is unimaginable and even more so because it is unnecessary and completely avoidable.”

“The killing and maiming of children is condemned as a grave violation against children, and perpetrators must be held to account,” he said.

Save the Children referenced remarks from UNICEF spokesperson James Elder, who after returning from Gaza, said on December 19 that around 1,000 children had lost one or both of their legs since October 7, when Hamas launched its attack on Israel and war broke out.

The charity also cited a World Health Organization statement in which the agency said many of these operations on children were conducted without anesthesia, given the severe shortages in medical supplies and basic goods in Gaza.

Lee said he had seen “doctors and nurses completely overwhelmed” when children are brought in with blast wounds.

“The impact of seeing children in that much pain and not having the equipment, medicines to treat them or alleviate pain is too much for even experienced professionals,” he said.

Children are nearly seven times more likely to die from blast injuries than adults as they are more vulnerable and sensitive to injuries, according to the charity.

“Their skulls are still not fully formed, and their undeveloped muscles offer less protection, so a blast is more likely to tear apart organs in their abdomen, even when there’s no visible damage,” Lee said, calling for a “definitive ceasefire” to allow the flow of humanitarian aid and medicines.

At least 22,835 Palestinians have been killed and 58,416 others injured in Gaza since October 7, the Hamas-run Palestinian Ministry of Health in Gaza said on Sunday.

Almost 90 percent of Gaza’s more than 2 million population has been forcibly displaced due to Israel’s war on Hamas, according to the United Nations Relief and Works Agency.

‘Deadly cycle’

The UN’s children’s agency has also warned of a triple threat to children in Gaza – not just the danger of raging conflict, but also of malnutrition and disease.

Cases of diarrhea in children under age 5 increased about 2,000 percent compared to before the war, UNICEF said.

“The significant increase in cases in such a short timeframe is a strong indication that child health in the Gaza Strip is fast deteriorating,” the agency said.

And 90 percent of children under age 2 are now subject to “severe food poverty,” it said – up from 80 percent just two weeks earlier.

“When combined and left untreated, malnutrition and disease create a deadly cycle,” UNICEF warned, adding that displaced families are facing poor hygiene conditions without access to safe water or plumbing.

Martin Griffiths, the UN’s top emergency relief official, warned last Friday that famine was “around the corner” as people in Gaza face the “highest levels of food insecurity ever recorded.”

A public health disaster is unfolding as sewers spill over and infectious diseases spread in overcrowded shelters, Griffiths said in the report, released by the UN’s Office for the Coordination of Humanitarian Affairs.

Around 180 Palestinian women “are giving birth daily amidst this chaos,” he added.

“Gaza has simply become uninhabitable. Its people are witnessing daily threats to their very existence — while the world watches on,” Griffiths said.

Written by Jessie Yeung, Radina Gigova and Mohammed Tawfeeq

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